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		<property:Field_data rdf:datatype="http://www.w3.org/2001/XMLSchema#string">##$a Inclui referências.</property:Field_data>
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		<property:Field_data rdf:datatype="http://www.w3.org/2001/XMLSchema#string">##$a A revisão taxonômica de Panaceae, apesar de sua proposição relativamente recente, é essencial devido à criação da família com base em uma representação limitada, derivada de apenas dois táxons. A aceitação dos gêneros Cymatoderma e Panus dentro de Panaceae é principalmente respaldada por análises filogenéticas moleculares. Tanto Cymatoderma quanto Panus, embora sejam gêneros proeminentes e amplamente distribuídos, têm uma história taxonômica complexa, e a sistemática desses gêneros permaneceu instável até a proposição de Panaceae. A taxonomia de Cymatoderma e Panus tem sido afetada tanto pela presença de várias espécies com numerosos sinônimos heterotípicos, descritas nos séculos 19 e 20, quanto à convergência morfológica que ambos gêneros apresentam com outras famílias de Polyporales, fazendo com que sejam facilmente confundidos. Desta forma uma revisão abrangente do gênero é necessária. As espécies descritas no Brasil e aquelas com registros de ocorrência também carecem de coletas e revisões adicionais. Embora evidências moleculares tenham sido utilizadas para delimitar algumas espécies no Brasil, várias espécies ainda não foram submetidas a esse tipo de análise. Com o propósito de esclarecer a diversidade de espécies, garantir uma identificação mais precisa e realizar uma filogenia representativa de Panaceae, foram conduzidos estudos com espécies que ocorrem no Brasil. Análises morfológicas e filogenéticas (moleculares: nrITS, nrLSU, RPB1 e tef1-α) foram realizadas. Panaceae é constituída por pelo menos 18 clados, dos quais 4 são propostos neste trabalho como novas espécies, juntamente com 2 epitificações e 4 novas combinações. Endopandanicola thailandicus (espécie endófita) está sendo sinonimizada e combinada no gênero Panus. Apresento, adicionalmente, uma chave de identificação, definições de sensu stricto e resoluções nomenclaturais, quando necessário, para as espécies em Panaceae. A partir do levantamento dos dados, foi possível também avaliar o estado de conservação de uma das espécies, a qual foi classificada como quase ameaçada conforme critérios da IUCN (International Union for Conservation of Nature).</property:Field_data>
		<property:Field_data rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8#$a Abstract: Recent advances in the development of nanomaterials have allowed their application in the controlled release of drugs for local treatment against cancer. However, despite the numerous systems reported in this area, the accumulation low rate of the nanomaterials in the biological systems remains a challenge. Polymeric nanoparticles (Nps) homogeneously distributed in polymer nanofibers (Nfs) formed by eletrospinning are an alternative to overcome these challenges. Thus, in this doctoral theses, a new nanomaterial was developed by dispersion of the Nps of carboxymethyl hexanoyl chitosan/dodecyl sulfate (CHQ-SDS) in PEO/chitosan Nfs (PEOCh-H3). The nanomaterial was applied in the controlled release of pyrazoline (H3TM04), which have activity against leukemia and melanoma cancer cells. The thesis was developed in 3 stages: i) A fundamental study, to understand the interaction process and nanoaggregates formation of the carboxymethyl hexanoyl chitosan / dodecyl sulfate. ii) Formation of CHQ-SDS Nps applied in the encapsulation and in vitro assays against leukemic cells. iii) The formation of the Nfs PEOCh-H3 by eletrospinning, and applied in vitro and ex vivo release of H3TM04 in melanoma cells and human skin. The formation of CHQ-SDS nanoaggregates occurs by hydrophobic assembly between the SDS and CHQ, where this is a thermodynamically favorable process. On the other hand, the presence of SDS decreases the hydrodynamic radius and surface charge of the nanoaggregates, increasing the colloidal stability in aqueous solution for up to 150 days. The CHQ-SDS Nps were formed at pH 7.4 and characterized by dynamic light scattering, electron transmission microscopy and zeta potential, showed a spherical morphology. The encapsulation efficiency of H3TM04 was 96% and the nanoparticles had 83,9 ± 1,2 nm of the hydrodynamic radius. The in vitro release results demonstrated that the active compound release process occurs by the Nps erosion, decreasing the inhibitory concentration (IC50) for leukemia cells (Jukat and K-562). Finally, the PEOCh-H3 nanofibers were formed and characterized by thermal and microscopic techniques. The Nps were evidenced within the Nfs by transmission electron microscopy. in vitro studies demonstrated that the release process of H3TM04 occurs by diffusion and erosion of the nanomaterial during 120 h. On the other hand, PEOCh-H3 increases the accumulation of the active compounds in the epidermis (ex vivo release test on human skin), as well as increases the cytotoxic effect of H3TM04 in melanoma cells (in vitro test). This double release barrier (Nfs/Nps) is a promising candidate for the controlled release of drugs to increases the accumulation rate of the active compound in the biological tissue.</property:Field_data>
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		<property:Field_data rdf:datatype="http://www.w3.org/2001/XMLSchema#string">04$a Biologia de fungos</property:Field_data>
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		<property:Field_data rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1#$a Santos, Elisandro Ricardo Drechsler dos, $e orientador</property:Field_data>
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		<property:Field_data rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2#$a Universidade Federal de Santa Catarina. $b Programa de Pós-Graduação em Biologia de Fungos, Algas e Plantas</property:Field_data>
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		<property:Field_data rdf:datatype="http://www.w3.org/2001/XMLSchema#string">40$z Versão integral em pdf $u https://bu.ufsc.br/teses/PBFA0108-T.pdf</property:Field_data>
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