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		<property:Field_data rdf:datatype="http://www.w3.org/2001/XMLSchema#string">##$a Este trabalho apresenta um estudo sobre a utilização de algoritmos baseados em redes neurais artificiais aplicadas ao controle da tensão de saída e correção de fator de potência de um retificador Buck, que deu origem a um Adaptive Neural Network Controller (ANNC), o qual emprega as técnicas Feedforward Current do indutor de saída e neurônio aditivo, onde a ação de controle se dá por meio da razão cíclica aplicada ao acionamento do transistor de potência. O aprendizado aplicado ao ANNC possui característica de tempo real, sem a necessidade de treinamento prévio portanto, o sistema se adapta as mudanças regulando a tensão e corrigindo o fator de potência instantaneamente. A simulação do ANNC utilizou o software PSIM, onde são analisadas as respostas dinâmicas do retificador Buck frente ao degrau na potência de saída e seus efeitos quanto: a estabilidade da tensão na carga, a manutenção do fator de potência praticamente unitário, e o baixo conteúdo harmônico da corrente de entrada. Neste trabalho são apresentados os resultados de simulação e experimental, onde é possível observar que as técnicas empregadas, Feedforward Current e neurônio aditivo, promovem o ajuste da tensão de saída conforme a referência e mantém um fator de potência praticamente unitário. No intuito de comprovar a aplicação da técnica apresentada, um protótipo de 1500W, 220V de tensão de entrada, e até 60V de tensão de saída foi implementado, onde foram obtidos resultados de acordo com o intervalo dos ensaios realizados, alcançando um fator de potência de 0, 9932 com uma Distorção Harmônica Total na ordem de 5, 94%.</property:Field_data>
		<property:Field_data rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8#$a Abstract: Abstract: Recent advances in the development of nanomaterials have allowed their application in the controlled release of drugs for local treatment against cancer. However, despite the numerous systems reported in this area, the accumulation low rate of the nanomaterials in the biological systems remains a challenge. Polymeric nanoparticles (Nps) homogeneously distributed in polymer nanofibers (Nfs) formed by eletrospinning are an alternative to overcome these challenges. Thus, in this doctoral theses, a new nanomaterial was developed by dispersion of the Nps of carboxymethyl hexanoyl chitosan/dodecyl sulfate (CHQ-SDS) in PEO/chitosan Nfs (PEOCh-H3). The nanomaterial was applied in the controlled release of pyrazoline (H3TM04), which have activity against leukemia and melanoma cancer cells. The thesis was developed in 3 stages: i) A fundamental study, to understand the interaction process and nanoaggregates formation of the carboxymethyl hexanoyl chitosan / dodecyl sulfate. ii) Formation of CHQ-SDS Nps applied in the encapsulation and in vitro assays against leukemic cells. iii) The formation of the Nfs PEOCh-H3 by eletrospinning, and applied in vitro and ex vivo release of H3TM04 in melanoma cells and human skin. The formation of CHQ-SDS nanoaggregates occurs by hydrophobic assembly between the SDS and CHQ, where this is a thermodynamically favorable process. On the other hand, the presence of SDS decreases the hydrodynamic radius and surface charge of the nanoaggregates, increasing the colloidal stability in aqueous solution for up to 150 days. The CHQ-SDS Nps were formed at pH 7.4 and characterized by dynamic light scattering, electron transmission microscopy and zeta potential, showed a spherical morphology. The encapsulation efficiency of H3TM04 was 96% and the nanoparticles had 83,9 ± 1,2 nm of the hydrodynamic radius. The in vitro release results demonstrated that the active compound release process occurs by the Nps erosion, decreasing the inhibitory concentration (IC50) for leukemia cells (Jukat and K-562). Finally, the PEOCh-H3 nanofibers were formed and characterized by thermal and microscopic techniques. The Nps were evidenced within the Nfs by transmission electron microscopy. in vitro studies demonstrated that the release process of H3TM04 occurs by diffusion and erosion of the nanomaterial during 120 h. On the other hand, PEOCh-H3 increases the accumulation of the active compounds in the epidermis (ex vivo release test on human skin), as well as increases the cytotoxic effect of H3TM04 in melanoma cells (in vitro test). This double release barrier (Nfs/Nps) is a promising candidate for the controlled release of drugs to increases the accumulation rate of the active compound in the biological tissue.</property:Field_data>
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		<property:Field_data rdf:datatype="http://www.w3.org/2001/XMLSchema#string">04$a Engenharia de sistemas eletrônicos</property:Field_data>
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		<property:Field_data rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1#$a Greff, Diego Santos, $e orientador</property:Field_data>
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		<property:Field_data rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2#$a Universidade Federal de Santa Catarina. $b Programa de Pós-Graduação em Engenharia de Sistemas Eletrônicos</property:Field_data>
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		<property:Field_data rdf:datatype="http://www.w3.org/2001/XMLSchema#string">40$z Versão integral em pdf $u https://bu.ufsc.br/teses/PESE0023-D.pdf</property:Field_data>
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